Bases de Dados

 

Additional Molecular Biology Databases

Each year Nucleic Acids Research publishes a special issue describing a wide variety of databases containing useful compilations of sequence and other information. The following list of molecular biology databases was complied by Dr. Andreas D. Baxevanis with an emphasis on including databases where new value is added to the underlying data by virtue of curation, new data connections or other innovative approaches. It is also available at: http://nar.oupjournals.org/.
Major Sequence Repositories Comparative Genomics Gene Expression
Gene Identification and Structure   Genetic Maps Genomic Databases
Intermolecular Interactions Metabolic Pathways and Cellular Regulation   Mutation Databases
Pathology Protein Databases Protein Sequence Motifs
Proteome Resources Retrieval Systems and Database Structure RNA Sequences
Structure Transgenics Varied Biomedical Content  
Database URL Description
 
Major Sequence Repositories    
GenBank www.ncbi.nlm.nih.gov/Web/Genbank/ All known nucleotide and protein sequences
EMBL Nucleotide Sequence Database www.ebi.ac.uk/embl.html All known nucleotide and protein sequences
DNA Data Bank of Japan (DDBJ) www.ddbj.nig.ac.jp All known nucleotide and protein sequences
Genome Sequence Database (GSDB) www.ncgr.org/gsdb All known nucleotide and protein sequences
TIGR Gene Indices www.tigr.org/tdb/tdb.html Non-redundant, gene-oriented clusters
UniGene www.ncbi.nlm.nih.gov/UniGene/ Non-redundant, gene-oriented clusters
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Comparative Genomics

   

Clusters of Orthologous Groups (COG)

www.ncbi.nlm.nih.gov/COG Phylogenetic classification of proteins from 21 complete genomes

XREFdb

www.ncbi.nlm.nih.gov/XREFdb/ Cross-referencing of model organism genetics with mammalian phenotypes
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Gene Expression

   

ASDB

cbcg.nersc.gov/asdb Protein products and expression patterns of alternatively-spliced genes
Axeldb www.dkfz-heidelberg.de/abt0135/axeldb.htm Gene expression in Xenopus

BodyMap

bodymap.ims.u-tokyo.ac.jp Human and mouse gene expression data

EpoDB

www.cbil.upenn.edu/epodb Genes expressed in vertebrate RBC

FlyView

pbio07.uni-muenster.de/ Drosophila development and genetics
Gene Expression Database (GXD)

http://www.informatics.jax.org/mgihome/GXD/aboutGXD.shtml

Mouse gene expression and genomics

Kidney Development Database

www.ana.ed.ac.uk/anatomy/database/
kidbase/kidhome.html
Kidney development and gene expression

MAGEST

star.scl.kyoto-u.ac.jp/magest/ Ascidian (Halocynthia roretzi) gene expression patterns

Mouse Atlas and Gene Expression Database

genex.hgu.mrc.ac.uk Spatially-mapped gene expression data

PEDB

chroma.mbt.washington.edu/PEDB/ Normal and aberrant prostate gene expression

Tooth Development Database

honeybee.helsinki.fi/toothexp/toothdev.htm Gene expression in dental tissue
TRIPLES

ygac.med.yale.edu/triples/triples.htm

Transposon-Insertion Phenotypes, Localization, Expression in Saccharomyces

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Gene Identification and Structure    
Ares Lab Intron Site www.cse.ucsc.edu/research/compbio/
yeast_introns.html
Yeast spliceosomal introns
COMPEL compel.bionet.nsc.ru/FunSite.html Composite regulatory elements
CUTG www.kazusa.or.jp/codon/ Codon usage tables
EID mcb.harvard.edu/gilbert/EID/ Protein-coding, intron-containing genes
EPD www.epd.isb-sib.ch Eukaryotic POL II promoters
ExInt intron.bic.nus.edu.sg/exint/exint.html Exon-intron structure of eukaryotic genes
IDB/IEDB nutmeg.bio.indiana.edu/intron/index.html Intron sequence and evolution
PLACE www.dna.affrc.go.jp/htdocs/PLACE Plant cis-acting regulatory elements
PlantCARE sphinx.rug.ac.be:8080/PlantCARE Plant cis-acting regulatory elements
TransTerm uther.otago.ac.nz/Transterm.html Codon usage, start and stop signals
TRRD wwwmgs.bionet.nsc.ru/mgs/dbases/trrd4/ Regulatory regions of eukaryotic genes
YIDB www.EMBL-Heidelberg.DE/ExternalInfo/
seraphin/yidb.html
Yeast nuclear and mitochondrial intron sequences
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Genetic Maps

   
GeneMap '99 www.ncbi.nlm.nih.gov/genemap/ International Radiation Mapping Consortium human gene map
G3-RH www-shgc.stanford.edu/RH/ Stanford G3 and TNG radiation hybrid maps
GB4-RH www.sanger.ac.uk/RHserver/RHserver.shtml Genebridge4 (GB4) human radiation hybrid maps
GDB www.gdb.org Human genes and genomic maps
DRESH www.tigem.it/LOCAL/drosophila/dros.html Human cDNA clones homologous to Drosophila mutant genes
GenAtlas www.citi2.fr/GENATLAS/ Human genes, markers, and phenotypes
HuGeMap www.infobiogen.fr/services/Hugemap Human genome genetic and physical map data
IXDB ixdb.mpimg-berlin-dahlem.mpg.de Physical maps of human chromosome X
Radiation Hybrid Database www.ebi.ac.uk/RHdb Radiation hybrid map data
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Genomic Databases    
ACeDB www.sanger.ac.uk/Software/Acedb/ C. elegans, S. pombe, and human sequences and genomic information
FilGenNet www.neb.com/fgn/filgen1.html Genome research on filarial nematode parasites of humans
FlyBase www.fruitfly.org Drosophila sequences and genomic information
Mouse Genome Database (MGD) www.informatics.jax.org Mouse genetics and genomics
Saccharomyces Genome Database (SGD) genome-www.stanford.edu/Saccharomyces Saccharomyces cerevisiae genome
AMmtDB bio-www.ba.cnr.it:8000/BioWWW/#AMMTDB Metazoan mitochondrial DNA sequences
Arabidopsis Database (AtDB) www.arabidopsis.org/search/ Arabidopsis thaliana genome
CropNet synteny.nott.ac.uk Genome mapping in crop plants
CyanoBase www.kazusa.or.jp/cyano/mutants Synechocystis sp. genome
EcoGene bmb.med.miami.edu/EcoGene/EcoWeb E. Coli K-12 sequences
EMGlib pbil.univ-lyon1.fr/emglib/emglib.html Completely sequenced bacterial genomes and the yeast genome
GOBASE megasun.bch.umontreal.ca/gobase/gobase.html Organelle genome database
HIV Sequence Database hiv-web.lanl.gov/ RNA sequences
Human BAC Ends Database www.tigr.org/tdb/humgen/bac_end_search/
bac_end_intro.html
Non-redundant human BAC end sequences
INE www.dna.affrc.go.jp:82/giot/INE.html Rice genetic and physical maps and sequence data
MitBASE www3.ebi.ac.uk/Research/Mitbase/mitbase.pl

Mitochondrial genomes, intra-species variants, and mutants

MitoDat www-lecb.ncifcrf.gov/mitoDat/ Mitochondrial proteins (predominantly human)
MITOMAP www.gen.emory.edu/mitomap.html Human mitochondrial genome
MITONUC/MITOALN bio-www.ba.cnr.it:8000/srs6/ Nuclear genes coding for mitochondrial proteins
Munich Info Center for Protein Seqs (MIPS) www.mips.biochem.mpg.de Protein and genomic sequences
NRSub pbil.univ-lyon1.fr/nrsub/nrsub.html Bacillus subtilis genome
TIGR Microbial Database www.tigr.org/tdb/mdb/mdb.html Microbual genomes and chromosomes
ZFIN zfish.uoregon.edu/ZFIN/

Zebrafish genetics and development; mutant and wild-type lines

ZmDB zmdb.iastate.edu/ Maize genome database
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Intermolecular Interactions

   

Database of Ribosomal Crosslinks (DRC)

www.mpimg-berlin-dahlem.mpg.de/~ag_ribo/
ag_brimacombe/drc/
Ribosomal crosslinking data
DIP

dip.doe-mbi.ucla.edu/

Catalog of protein-protein interactions

DPInteract

arep.med.harvard.edu/dpinteract/ Binding sites for E. coli DNA-binding proteins
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Metabolic Pathways and Cellular Regulation    
Kyoto Encycl. of Genes and Genomes (KEGG) www.genome.ad.jp/kegg Metabolic and regulatory pathways
EcoCyc ecocyc.pangeasystems.com/ecocyc E. coli K-12 genome, gene products, and metabolic pathways
ENZYME www.expasy.ch/enzyme/ Enzyme nomenclature
EpoDB cbil.humgen.upenn.edu/epodb Genes expressed during human erythropoiesis
FlyNets gifts.univ-mrs.fr/FlyNets/FlyNets_home_page.html Drosophila melanogaster molecular interactions
Klotho www.ibc.wustl.edu/klotho/ Collection and categorization of biological compounds
LIGAND www.genome.ad.jp/dbget/ligand.html Enzymatic ligands, substrates, and reactions
RegulonDB www.cifn.unam.mx/Computational_Biology/
regulondb/
E. coli pathways and regulation
UM-BBD www.labmed.umn.edu/umbbd/ Microbial biocatalytic reactions and biodegradation pathways
WIT2 wit.mcs.anl.gov/WIT2/ System for functional curation and development of metabolic models
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Mutation Databases

   
Online Mendelian Inheritance in Man

www.ncbi.nlm.nih.gov/Omim/

Catalog of human genetic and genomic disorders

ALFRED

fondue.med.yale.edu/ Allele frequencies and DNA polymorphisms
Androgen Receptor Gene Mutations

www.mcgill.ca/androgendb/

Mutations in the androgen receptor gene
Asthma and Allergy Database cooke.gsf.de  
Asthma Gene Database cooke.gsf.de/asthmagen/main.cfm Linkage and mutation studies on the genetics of asthma and allergy
Atlas of Genetics and Cytogenetics in Oncology www.infobiogen.fr/services/chromcancer/ Chromosomal abnormalities in cancer
BTKbase www.uta.fi/laitokset/imt/bioinfo/BTKbase/ Mutation registry for X-linked agammaglobulinemia
Cytokine Gene Polymorphism Database www.pam.bris.ac.uk/services/GAI/cytokine4.htm Cytokine gene polymorphisms, in vitro expression and disease-association
Database of Germline p53 Mutations www.lf2.cuni.cz/homepage.html Mutations in human tumor and cell line p53 gene
dbSNP www.ncbi.nlm.nih.gov/SNP Single nucleotide polymorphisms
GRAP Mutant Databases tinyGRAP.uit.no/GRAP/ Mutants of family A G-Protein Coupled Receptors (GRAP)
Haemophila B Mutation Database www.umds.ac.uk/molgen/haemBdatabase.htm Point mutations, short additions, and deletions in the Factor IX gene
HGBASE hgbase.interactiva.de/ Intragenic sequence polymorphisms
HIV-RT hivdb.stanford.edu/hiv/ HIV reverse transcriptase and protease sequence variation
Human Gene Mutation Database (HMGD) uwcm.web.cf.ac.uk/uwcm/mg/hgmd0.html Known (published) gene lesions responsible for human inherited disease
Human PAX2 Allelic Variant Database www.hgu.mrc.ac.uk/Softdata/PAX2/ Mutations in human PAX2 gene
Human PAX6 Allelic Variant Database www.hgu.mrc.ac.uk/Softdata/PAX6/ Mutations in human PAX6 gene
Human Type I and Type III Collagen Mutation www.le.ac.uk/genetics/collagen/ Human type I and type III collagen gene mutations
iARC p53 Database www.iarc.fr/p53/ Mis-sense mutations and small deletions in human p53
KinMutBase www.uta.fi/imt/bioinfo/KinMutBase/ Disease-causing protein kinase mutations
KMDB mutview.dmb.med.keio.ac.jp/mutview3/
kmeyedb/index.html
Mutations in human eye disease genes
Mutation Spectra Database info.med.yale.edu/mutbase/ Mutations in viral, bacterial, yeast, and mammalian genes
NCL Mutations www.ucl.ac.uk/ncl/ Mutations and polymorphisms in neuronal ceroid lipofuscinoses genes
p53 Databases metalab.unc.edu/dnam/mainpage.html Human p53 and hprt mutations; lacZ and lacI mutations
PAHdb www.mcgill.ca/pahdb/ Mutations at the phenylalanine hydroxylase locus
PMD pmd.ddbj.nig.ac.jp/ Compilation of protein mutant data
RB1 Gene Mutation Database home.kamp.net/home/ Mutations in the human retinoblastoma (RB1) gene
Ribosomal RNA Mutational Database ribosome.FandM.edu/ 16S and 23S ribosomal RNA mutation database
SV40 Large T-Antigen Mutant Database bigdaddy.bio.pitt.edu/SV40/ Mutations in SV40 large tumor antigen gene
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Pathology    
FIMM sdmc.krdl.org.sg:8080/fimm/ Functional molecular immunology data
Mouse Tumor Biology Database (MTB) tumor.informatics.jax.org Mouse tumor names, classification, incidence, pathology, genetic factors
PEDB www.mbt.washington.edu/PEDB/ Sequences from prostate tissue and cell type-specific cDNA libraries
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Protein Databases

   

AARSDB

rose.man.poznan.pl/aars/index.html Aminoacyl-tRNA synthetase sequences

DAtA

luggagefast.Stanford.EDU/group/arabprotein/ Annotated coding sequences from Arabidopsis

Endogenous GPCR List

www.biomedcomp.com/GPCR.html G protein-coupled receptors; expression in cell lines

ESTHER

www.ensam.inra.fr/cholinesterase/ Esterases and alpha/beta hydrolase enzymes and relatives

FUNPEP

swift.embl-heidelberg.de/FUNPEP/ Low-complexity or compositionally-biased protein sequences

GPCRDB

swift.embl-heidelberg.de/7tm/ G protein-coupled receptors

Histone Sequence Database

genome.nhgri.nih.gov/histones/ Histone and histone fold sequences and structures

HIV Molecular Immunology Database

hiv-web.lanl.gov/immunology/ HIV epitopes
Homeodomain Resource genome.nhgri.nih.gov/homeodomain Homeodomain sequences, structures, and related genetic information
HUGE www.kazusa.or.jp/huge Large (>50 kDa) human proteins and cDNA sequences
IMGT

www.ebi.ac.uk/imgt/hla/

Immunoglobulin, T cell receptor, and MHC sequences
InBase

www.neb.com/neb/inteins.html

Intervening protein sequences (inteins) and motifs

Kabat Database

immuno.bme.nwu.edu/ Sequences of proteins of immunological interest

LGIC

www.pasteur.fr/recherche/banques/LGIC/LGIC.html Ligand-gated ion channel sequences, alignments, and phylogeny
MEROPS www.bi.bbsrc.ac.uk/Merops/Merops.htm Peptidase sequences and structures

MHCPEP

wehih.wehi.edu.au/mhcpep/ MHC-binding peptides
NRR

nrr.georgetown.edu/nrr/NRR.html

Steroid and thyroid hormone receptor superfamily

Olfactory Receptor Database

ycmi.med.yale.edu/senselab/ordb/

Sequences for olfactory receptor-like molecules

ooTFD

www.ifti.org/ Transcription factors and gene expression
Peptaibol www.cryst.bbk.ac.uk/peptaibol/welcome.html

Peptaibol (antibiotic peptide) sequences

PhosphoBase

www.cbs.dtu.dk/databases/PhosphoBase Protein phosphorylation sites
PKR

delphi.phys.univ-tours.fr/Prolysis/

Protein kinase sequences, enzymology, genetics, and properties
PPMdb

sphinx.rug.ac.be:8080/ppmdb/index.html

Arabidopsis plasma membrane protein sequence and expression data
Prolysis delphi.phys.univ-tours.fr/Prolysis/ Proteases and natural and synthetic protease inhibitors

Receptor Database (RDP)

impact.nihs.go.jp/RDB.html Receptor protein sequences

Ribonuclease P Database

www.mbio.ncsu.edu/RNaseP/home.html RNase P sequences, alignments, and structures
SENTRA

wit.mcs.anl.gov/WIT2/Sentra/

Sensory signal transduction proteins

SWISS-PROT/TrEMBL

www.expasy.ch/sprot Curated protein sequences
TRANSFAC

transfac.gbf.de/TRANSFAC/index.html

Transcription factors and binding sites

Wnt Database

www.stanford.edu/~rnusse/wntwindow.html Wnt proteins and phenotypes
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Protein Sequence Motifs

   
BLOCKS

http://www.blocks.fhcrc.org/

Protein sequence motifs and alignments
PROSITE

www.expasy.ch/prosite/

Biologically-significant protein patterns and profiles
Pfam

www.sanger.ac.uk/Software/Pfam/

Multiple sequence alignments and hidden Markov models of protein domains
O-GLYCBASE www.cbs.dtu.dk/databases/OGLYCBASE/ Glycoproteins and O-linked glycosylation sites

PIR-ALN

www-nbrf.georgetown.edu/pirwww/
dbinfo/piraln.html
Protein sequence alignments
PRINTS

www.biochem.ucl.ac.uk/bsm/dbbrowser/PRINTS
/printscontents.html

Protein squence motifs and signatures
ProClass

pir.georgetown.edu/gfserver/proclass.html

Families defined by PROSITE patterns and PIR superfamilies
ProDom

www.toulouse.inra.fr/prodom.html

Protein domain families
ProtoMap www.protomap.cs.huji.ac.il/ Automated hierarchical classification of SWISS-PROT proteins
SMART coot.embl-Heidelberg.de/SMART/ Signalling domain sequences
SYSTERS www.dkfz-heidelberg.de/tbi/services/
cluster/systersform
Protein clusters
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Proteome Resources    
AAindex www.genome.ad.jp/dbget/ Physico-chemical properties of peptides
REBASE rebase.neb.com/rebase/rebase.html Restriction enzymes and associated methylases
SWISS-2DPAGE www.expasy.ch/ch2d/ 2D-PAGE images and reference maps
Yeast Proteome Database (YPD) www.proteome.com/YPDhome.html Saccharomyces cerevisiae proteome
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Retrieval Systems and Database Structure

   
KEYnet

www.ba.cnr.it/keynet.html

Keywords extracted from EMBL and GenBank
Virgil www.infobiogen.fr/services/virgil

Database interconnectivity

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RNA Sequences

   

ACTIVITY

wwwmgs.bionet.nsc.ru/systems/Activity/ Functional DNA/RNA site sequences

Collection of mRNA-like Noncoding RNAs

www.man.poznan.pl/5SData/ncRNA/ Non-protein-coding RNA transcripts
Database on the Structure of LS rRNA

rrna.uia.ac.be/

Alignment of large subunit ribosomal RNA sequences

Database on the Structure of SS rRNA

rrna.uia.ac.be/ssu Alignment of small subunit ribosomal RNA sequences
Intronerator

www.cse.ucsc.edu/~kent/intronerator/

RNA splicing and gene structure in C. elegans

Non-canonical Base Pair Database

prion.bchs.uh.edu/bp_type/ RNA structures containing rare base pairs
PLMItRNA bio-www.ba.cnr.it:8000/srs/

Plant mitochondrial tRNAs and tRNA genes

Pseudobase

wwwbio.leidenuniv.nl/~Batenburg/PKB.html

Information on RNA pseudo-knots

Ribosomal Database Project (RDP)

www.cme.msu.edu/RDP rRNA sequences, alignments, and phylogenies

RNA Modification Database

medlib.med.utah.edu/RNAmods Naturally modified nucleosides in RNA

SELEX_DB

wwwmgs.bionet.nsc.ru/mgs/systems/selex/ Selected DNA/RNA functional site sequences

Small RNA Database

mbcr.bcm.tmc.edu/smallRNA/smallrna.html Direct sequencing of small RNA sequences
SRPDB

psyche.uthct.edu/dbs/SRPDB/SRPDB.html

Signal recognition particle RNA, protein, and receptor sequences
tmRDB

psyche.uthct.edu/dbs/tmRDB/tmRDB.html

tmRNA (10Sa RNA) sequences

tmRNA Website

sunflower.bio.indiana.edu/~kwilliam/
tmRNA/home.html
tmRNA (10Sa RNA) sequences
UTRdb

bigarea.area.ba.cnr.it:8000/EmbIT/UTRHome/

5' and 3' UTRs of eukaryotic mRNAs

Viroid and Viroid-Like RNA Database

www.callisto.si.usherb.ca/~jpperra Viroid and viroid-like RNA and vHDV sequences
Yeast snoRNA Database www.bio.umass.edu/biochem/rna-sequence/
Yeast_snoRNA_Database/snoRNA_DataBase.html
Yeast small nucleolar RNAs
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Structure    
PDB

www.rcsb.org/pdb/

Structure data determined by X-ray crystallography and NMR
CATH

www.biochem.ucl.ac.uk/bsm/cath/

Hierarchical classification of protein domain structures
SCOP

scop.mrc-lmb.cam.ac.uk/scop/

Familial and structural protein relationships
ASTRAL astral.stanford.edu

Analysis of protein structures and their sequences

BioImage

www-embl.bioimage.org

Searchable database of multidimensional biological images
BioMagResBank www.bmrb.wisc.edu/

NMR spectroscopic data from proteins, peptides, and nucleic acids

CSD

www.ccdc.cam.ac.uk/prods/csd.html

Crystal structure information for organic and metal organic compounds
Database of Macromolecular Movements bioinfo.mbb.yale.edu/MolMovDB/ Descriptions of protein and macromolecular motions, including movies
Decoys `R' Us dd.stanford.edu/ Computer-generated protein conformations based on sequence data

HIC-Up

alpha2.bmc.uu.se/hicup/ Structures of small molecules ("hetero-compounds")

HSSP

www.sander.ebi.ac.uk/hssp/ Structural families and alignments; structurarly-conserved regions
IMB Jena Image Library

www.imb-jena.de/IMAGE.html

Visualization and analysis of three-dimensional biopolymer structures
ISSD www.protein.bio.msu.su/issd Integrated sequence and structural information
LPFC

www-smi.stanford.edu/projects/helix/LPFC/

Library of protein family core structures
MMDB www.ncbi.nlm.nih.gov/Structure/

All three-dimensional structures, linked to NCBI Entrez system

MODBASE

guitar.rockefeller.edu/modbase/

Comparative protein structure models

PDB-REPRDB

www.rwcp.or.jp/papia Representative protein chains, based on PDB entries

ProTherm

www.rtc.riken.go.jp/protherm.html Thermodynamic data for wild type and mutant proteins
RESID www-nbrf.georgetown.edu/pirwww/
dbinfo/resid.html

Protein structure modifications

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Transgenics

   

Cre Transgenic Database

www.mshri.on.ca/nagy/cre.htm Cre transgenic mouse lines

Transgenic/Targeted Mutation Database

tbase.jax.org/ Information on transgenic animals and targeted mutations
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Varied Biomedical Content

   

DBcat

www.infobiogen.fr/services/dbcat Catalog of databases

LocusLink/RefSeq

www.ncbi.nlm.nih.gov/LocusLink Curated sequence and descriptive information about genetic loci

Molecular Probe Database

srs.ebi.ac.uk/ Synthetic oligonucleotides, probes, and PCR primers
MPDB www.biotech.ist.unige.it/interlab/mpdb.html

Information on synthetic oligonucleotides

NCBI Taxonomy Browser

www.ncbi.nlm.nih.gov/Taxonomy/
taxonomyhome.html
Names of all organisms that are represented in the genetic databases
PubMed www.ncbi.nlm.nih.gov/PubMed/ MEDLINE and Pre-MEDLINE citations
Tree of Life phylogeny.arizona.edu/tree/phylogeny.html Information on phylogeny and biodiversity