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Anti-parallel β-sheet (backbone) This is an anti-parallel β-sheet: both aminoacid sequences have opposite orientations(check in which sense the N-Cα-C=O block repeats itself in each sequence). Observe how the atoms involved in H-bonding align themselevs in almost straight lines: H-bonds in anti-parallel β-sheets are therefore much stronger tahn those present in parallel β-sheets. Anti-parallel β-sheet (with sidechains) As in parallel β-sheets, the sidechains alternatedly poit upwards ands downwards from the sheet plane. Spin the structure in order to fully appreciate it. See how one of the ends of the sheet contains polar, hydrophylic residues, while the other mostly contains hydrophobic residues (and therefore it probably faces the protein core) Anti-parallel β-sheet in the protein The protein tertiary structure Other interactive models: Parallel β-sheet α-helix Anti-parallel β-sheet NADH dehidrogenase Succinate dehidrogenase Cytochrome bc1 complex Cytochrome c oxidase Hemoglobin Oxyhemoglobin (I) Oxyhemoglobin (II) Metabolic pathways: Fatty acids metabolism Glycolysis Citric acid cycle Fermentation and respiration Glycogen synthesis and glycogenolysis Gluconeogenesis Aminoacid degradation and urea cycle Pentose phosphate pathway Metabolic regulation and integration visitas desde 4 de Janeiro de 2002
This is an anti-parallel β-sheet: both aminoacid sequences have opposite orientations(check in which sense the
N-Cα-C=O
Anti-parallel β-sheet (with sidechains) As in parallel β-sheets, the sidechains alternatedly poit upwards ands downwards from the sheet plane. Spin the structure in order to fully appreciate it. See how one of the ends of the sheet contains polar, hydrophylic residues, while the other mostly contains hydrophobic residues (and therefore it probably faces the protein core) Anti-parallel β-sheet in the protein The protein tertiary structure Other interactive models: Parallel β-sheet α-helix Anti-parallel β-sheet NADH dehidrogenase Succinate dehidrogenase Cytochrome bc1 complex Cytochrome c oxidase Hemoglobin Oxyhemoglobin (I) Oxyhemoglobin (II) Metabolic pathways: Fatty acids metabolism Glycolysis Citric acid cycle Fermentation and respiration Glycogen synthesis and glycogenolysis Gluconeogenesis Aminoacid degradation and urea cycle Pentose phosphate pathway Metabolic regulation and integration visitas desde 4 de Janeiro de 2002
As in parallel β-sheets, the sidechains alternatedly poit upwards ands downwards from the sheet plane. Spin the structure in order to fully appreciate it. See how one of the ends of the sheet contains polar, hydrophylic residues, while the other mostly contains hydrophobic residues (and therefore it probably faces the protein core)
Anti-parallel β-sheet in the protein The protein tertiary structure Other interactive models: Parallel β-sheet α-helix Anti-parallel β-sheet NADH dehidrogenase Succinate dehidrogenase Cytochrome bc1 complex Cytochrome c oxidase Hemoglobin Oxyhemoglobin (I) Oxyhemoglobin (II) Metabolic pathways: Fatty acids metabolism Glycolysis Citric acid cycle Fermentation and respiration Glycogen synthesis and glycogenolysis Gluconeogenesis Aminoacid degradation and urea cycle Pentose phosphate pathway Metabolic regulation and integration visitas desde 4 de Janeiro de 2002
The protein tertiary structure Other interactive models: Parallel β-sheet α-helix Anti-parallel β-sheet NADH dehidrogenase Succinate dehidrogenase Cytochrome bc1 complex Cytochrome c oxidase Hemoglobin Oxyhemoglobin (I) Oxyhemoglobin (II) Metabolic pathways: Fatty acids metabolism Glycolysis Citric acid cycle Fermentation and respiration Glycogen synthesis and glycogenolysis Gluconeogenesis Aminoacid degradation and urea cycle Pentose phosphate pathway Metabolic regulation and integration visitas desde 4 de Janeiro de 2002
Parallel β-sheet α-helix Anti-parallel β-sheet NADH dehidrogenase Succinate dehidrogenase Cytochrome bc1 complex Cytochrome c oxidase Hemoglobin Oxyhemoglobin (I) Oxyhemoglobin (II)
Fatty acids metabolism Glycolysis Citric acid cycle Fermentation and respiration Glycogen synthesis and glycogenolysis Gluconeogenesis Aminoacid degradation and urea cycle Pentose phosphate pathway Metabolic regulation and integration