2FUG - NADH dehydrogenase (complex I)
Sazanov and Hinchliffe (2006) Science, 311, 1430
NADH dehydrogenase catalyzes electron transport from NADH to ubiquinone. It contains a large number of subunits, fourteen of which are conserved across species. It contains a transmembrane portion (with 7 conserved subunits), which carries electrons to ubiquinone, and a soluble portion (with 7 conserved subunits) which accepts electrons from NADH. These electrons are transferred to a
.flavin mononucleotide (FMN).
They are then sequentially transferred to a
Fe-S cluster chain .
The model shown only includes a soluble moiety of the complex. Reduction of ubiquinone to ubiquinol by the electrons carried by the Fe-S clusters cannot be shown, since it occurs in the membrane portion of the complex.
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